Clorgyline-induced modification of behavioral sensitization to quinpirole: Effects on local cerebral glucose utilization

Effects of quinpirole on behavioral extinction.

Behavioral effects of quinpirole (QNP), a dopamine D(2) receptor agonist, suggest it impacts neural mechanisms mediating goal-directed behaviors, as well as behavioral extinction following removal of a primary reinforcer. The present study investigated the effect of QNP on behavioral extinction following the omission of contingent reinforcement, and whether this effect is related to acquisition...

Coupling of local cerebral blood flow to local cerebral glucose utilization during isoflurane and sevoflurane anesthesia.

Effects of ageing on local rates of cerebral glucose utilization in the rat.

The effects of ageing on local rates of glucose utilization in 47 brain structures in resting conscious rats have been examined. Three age groups have been studied: young adult (4 to 6 months), middle-aged (14 to 16 months), and aged (26 to 36 months). The results show that ageing per se is associated with decreases in rates of glucose utilization in specific brain regions. The decreases were n...

Effects of quinpirole on operant conditioning: perseveration of behavioral components.

Quinpirole (QNP) is reported to elicit repetitive spontaneous behaviors as well as reduce extinction of operant responses. To determine whether these effects represent perseveration of learned behaviors, behavioral components were examined during the acquisition and extinction of operant responses. Rats, receiving either 0, 0.08, or 0.60 mg/kg QNP were trained to nose poke to receive water. The...

Effects of nicotine on local cerebral glucose utilization in the rat.

We used the autoradiographic 2-deoxy-D-[1-14C]glucose (14C-DG) method of Sokoloff to identify brain areas with altered rates of local cerebral glucose utilization (LCGU) in vivo in response to peripheral I-nicotine administration (0.1, 0.3, 1.0, and 1.75 mg/kg, s.c.). Nicotine stimulated LCGU primarily in areas reported to contain nicotine binding sites, indicating that the sites are true recep...